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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The genetic sexing of animals having long gestation periods offers significant benefits in regard to breeding management among their populations living in captivity. In our study, a new increased-sensitivity PCR method for fetal sexing was developed and tested successfully on elephants, from only a small volume of maternal plasma.
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Prenatal cell-free DNA screening - Mayo Clinic

Prenatal cell-free DNA cfDNA screening, also known as noninvasive prenatal screening, is a method to screen for certain chromosomal abnormalities in a fetus. During prenatal cell-free DNA screening, DNA from the mother and fetus is extracted from a maternal blood sample and screened for the increased chance of specific chromosome problems, such as Down syndrome, trisomy 13 and trisomy This screening can also provide information about fetal sex. Prenatal cell-free DNA screening is recommended for women who are at least 10 weeks pregnant and have adequate counseling regarding the options, benefits and limits of first and second trimester screening and diagnostic testing. Your health care provider or a genetic counselor will discuss whether prenatal cell-free DNA screening might benefit you and how to interpret the results. Prenatal cell-free DNA screening is available to anyone who is pregnant.
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Noninvasive Fetal Sex Determination Using Cell-Free Fetal DNA

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Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides an alternative to invasive techniques for some heritable disorders. In some countries this testing has transitioned to clinical care, despite the absence of a formal assessment of performance. To document overall test performance of noninvasive fetal sex determination using cell-free fetal DNA and to identify variables that affect performance. Systematic review and meta-analysis with search of PubMed January 1, —April 17, to identify English-language human studies reporting primary data. References from review articles were also searched.
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