Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures. A prospective, randomized, placebo-controlled, double blind, crossover trial. Efeito da pimenta vermelha nos sintomas de pacientes com fissuras anais agudas. AIM: To determine if consumption of chilies increases symptoms of acute anal fissures. METHODS: Individual patients were randomized to receive capsules containing chili or placebo for one week in addition to analgesics and fiber supplement.
Rectal administration - Wikipedia
Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels , [Note 1] and flow into the body's circulatory system , which distributes the drug to the body's organs and bodily systems. A drug that is administered rectally will in general depending on the drug have a faster onset, higher bioavailability , shorter peak, and shorter duration than oral administration. In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic middle and inferior rectal vein and one third hepatic portal system superior rectal vein. This means the drug will reach the circulatory system with significantly less alteration and in greater concentrations. Unlike intravenous lines, which usually need to be placed in an inpatient environment and require special formulation of sterile medications,  a specialized rectal catheter can be placed by a clinician, such as a hospice nurse or home health nurse, in the home. Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia , ileus , or bowel obstruction , that would interfere with the progression of the medication through the tract.
Alcohol consumption and rectal tumor mutations and epigenetic changes
An association between alcohol and rectal cancer has been reported in the epidemiological literature. In this study we further explore the association by examining specific tumor markers with alcohol consumption as well as types of alcoholic beverages consumed. We evaluated type, long-term, and recent alcohol consumption. We observed a trend toward increasing risk of CpG Island Methylator Phenotype positive tumors and long-term alcohol consumption.
An alcohol enema , also known colloquially as butt-chugging , is the act of introducing alcohol into the rectum and colon via the anus , i. This method of alcohol consumption can be dangerous and even deadly because it leads to faster intoxication since the alcohol is absorbed directly into the bloodstream and bypasses the body's ability to reject the toxin by vomiting. Two reported techniques specific to alcohol enemas are by inserting into the rectum either an alcohol-soaked tampon  or tubing connected to a funnel into which alcohol is poured,  known as a beer bong. Enema bags of the sort used medically, e. An alcohol enema is a faster method of alcohol intoxication since the alcohol is absorbed directly into the bloodstream.